New treatments and therapeutic strategies for acne
New treatments and therapeutic strategies for acne ~ Successful management of acne requires careful patient evaluation followed by consideration of several patient and medication factors when selecting a particular therapeutic regimen. Within the last few years, several new agents for the treatment of acne have become available that afford greater flexibility in the treatment of [...]
August 30, 2012 | Posted in : Skin Care | There’s no comment yet | » read more . . .
How I treat relapsed childhood acute lymphoblastic leukemia
How I treat relapsed childhood acute lymphoblastic leukemia ~ The most common cause of treatment failure in childhood acute lymphoblastic leukemia (ALL) remains relapse, occurring in approximately 15-20% of patients. Survival of relapsed patients can be predicted by site of relapse, length of first complete remission and immunophenotype of relapsed ALL. Bone marrow (BM) and [...]
August 30, 2012 | Posted in : Health & Medicine | There’s no comment yet | » read more . . .
MicroRNAs characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia
MicroRNAs characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia ~ esign and Methods. Expression levels of 397 microRNAs (including novel microRNAs) were measured by quantitative real-time polymerase-chain-reaction in 81 pediatric leukemia cases and 17 normal hematopoietic control cases. Results. Except for BCR-ABL-positive and B-other acute lymphoblastic leukemia, all other major subtypes i.e. [...]
August 30, 2012 | Posted in : Health & Medicine | There’s no comment yet | » read more . . .
Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia ~ I. CLINICAL MANAGEMENT OF ADULT ALL Dieter Hoelzer, MD PhD,* Nicola Gökbuget, MD, and Oliver Ottmann, MD In adult acute lymphoblastic leukemia (ALL) complete remission (CR) rates of 80-85% and leukemia-free sur- vival (LFS) rates of 30-40% can be achieved (Table 1). Intensified consolidation, particularly with high-dose methotrexate (HDM) and high-dose [...]
August 30, 2012 | Posted in : Health & Medicine | There’s no comment yet | » read more . . .
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimers disease model
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimers disease model ~ Alzheimer’s disease (AD) is a neurodegenerative disorder char- acterized by a progressive loss of cognitive abilities and by neu- ropathological features including amyloid deposits, neurofibrillary tangles, and neuronal loss in selective brain regions. Amyloid deposits are extracellular proteinaceous aggregates characteristically seen [...]
August 29, 2012 | Posted in : Health & Medicine | There’s no comment yet | » read more . . .
Translating cell biology into therapeutic advances in Alzheimers disease
Translating cell biology into therapeutic advances in Alzheimers disease ~ Three central questions about Alzheimer’s syndrome It is now clear that AD is, in reality, a multifactorial syndrome, rather than a single disease. Given the complex array of factors that may initiate or propagate the syndrome, it sometimes seems that researchers are pursuing many ostensibly [...]
August 29, 2012 | Posted in : Health & Medicine | There’s no comment yet | » read more . . .
Ab peptide immunization reduces behavioural impairment and plaques in a model of Alzheimers disease
Ab peptide immunization reduces behavioural impairment and plaques in a model of Alzheimers disease ~ Because the main analysis revealed significant immunogen × genotype (P , 0.01) and immunogen × genotype × age (P , 0.05) interactions, as well as significant main factor effects for immuno- gen, genotype and age of testing (P , 0.01 [...]
August 29, 2012 | Posted in : Health & Medicine | There’s no comment yet | » read more . . .
Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein
Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein ~ SUMMARY: A purified protein derived from the twisted E-pleated sheet fibrils in cerebrovascular amyloidosis associated with Alzheimer’s disease has been isolated by Sephadex G-100 column chromatography with 5 M guanidine-HCl in 1 N acetic acid and by high performance [...]
August 29, 2012 | Posted in : Health & Medicine | There’s no comment yet | » read more . . .
USPchapter 797: Establishing a practice standard for compounding sterile preparations in pharmacy
USPchapter 797: Establishing a practice standard for compounding sterile preparations in pharmacy ~ No one single event is affecting the profession of pharmacy as is chapter 797 of The United States Pharmacopeia and The National Formulary (USP), entitled Pharmaceutical Compounding—Sterile Preparations.1 Pharmacists have been compounding for hundreds of years and take pride in being critical [...]
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Using a closed-system protective device to reduce personnel exposure to antineoplastic agents
Using a closed-system protective device to reduce personnel exposure to antineoplastic agents ~ Before 1980, standard practices for manipulating antineoplastic agents generally involved the use of horizontal-laminar-airflow hoods, with very limited use of personal protective equipment. During the 1980s, anecdotal reports and quantitative studies began appearing that highlighted the potential dangers associated with preparing and [...]
August 29, 2012 | Posted in : Health & Medicine | There’s no comment yet | » read more . . .
Sexual Dimorphisms in a Neuromuscular System Regulating Courtship in the Green Anole Lizard: Effects of Season and Androgen Treatment
Sexual Dimorphisms in a Neuromuscular System Regulating Courtship in the Green Anole Lizard: Effects of Season and Androgen Treatment ~ Dewlap extension is induced by the contraction of a bilaterally symmetrical muscle (M. ceratohyoideus, also called M. branchiohyoideus) in the throat, which causes a piece of cartilage (second ceratobranchial cartilage, also called “retrobasal process”) (Crews, [...]
August 29, 2012 | Posted in : Science | There’s no comment yet | » read more . . .
COMMUNICATING THE HISTORY OF CHEMISTRY
COMMUNICATING THE HISTORY OF CHEMISTRY ~ Over two dozen periodicals have originated since 1823, in which subjects on history or philosophy of science (including chemistry, of course), have been published. Many of these are listed in Table 1 in chronological order of their appearance. Because the coverage in most of these journals is much broader [...]
August 29, 2012 | Posted in : Science | There’s no comment yet | » read more . . .
